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Zhang, Xiaochang
One or more keywords matched the following properties of Zhang, Xiaochang
PropertyValue
keywords Cell type specification
overview How our brain is developed and evolved remains a major question, and abnormal development of the human brain can cause autism, epilepsy and intellectual disability. We study fundamental mechanisms of brain development and disorders. Our current research includes: mechanisms of cell type specification in mammalian brains, genetics of neurodevelopmental disorders, and roles of mRNA isoforms in neural development and diseases. We develop and apply single-cell approaches, animal models, and functional genomics to address these questions.
One or more keywords matched the following items that are connected to Zhang, Xiaochang
Item TypeName
Concept Brain Diseases
Concept Amino Acyl-tRNA Synthetases
Concept Cerebral Cortex
Concept Cell Differentiation
Concept Cell Movement
Concept Cell Nucleus
Concept Binding Sites
Concept Cell Division
Concept Bromodeoxyuridine
Concept Chromosome Deletion
Concept Child, Preschool
Concept Exons
Concept Introns
Concept Microtubule-Associated Proteins
Concept Dyneins
Concept Membrane Proteins
Concept Microcephaly
Concept Nerve Tissue Proteins
Concept Intellectual Disability
Concept Mice, Inbred C57BL
Concept Pedigree
Concept Repressor Proteins
Concept RNA
Concept Starvation
Concept Caenorhabditis elegans
Concept RNA Splice Sites
Concept HMGA2 Protein
Concept Alternative Splicing
Concept Protein Structure, Tertiary
Concept RNA-Binding Proteins
Concept Cell Proliferation
Concept Centrosome
Concept Malformations of Cortical Development
Concept Single-Cell Analysis
Concept 3' Untranslated Regions
Concept ras GTPase-Activating Proteins
Concept Databases, Genetic
Concept Lissencephaly
Concept Agenesis of Corpus Callosum
Concept Periventricular Nodular Heterotopia
Concept DNA Copy Number Variations
Concept T-Box Domain Proteins
Concept Caenorhabditis elegans Proteins
Concept Polypyrimidine Tract-Binding Protein
Concept Chromosome Disorders
Concept Neural Stem Cells
Concept Basic Helix-Loop-Helix Transcription Factors
Concept Transcriptome
Concept Heterogeneous-Nuclear Ribonucleoproteins
Concept POU Domain Factors
Concept Classical Lissencephalies and Subcortical Band Heterotopias
Concept Cells, Cultured
Concept Chromosomes, Human, Pair 16
Concept Cytoskeletal Proteins
Concept Hydrocephalus
Concept Magnetic Resonance Imaging
Concept Nuclear Proteins
Concept Seizures
Concept Genetic Predisposition to Disease
Concept Protein Isoforms
Concept Telomere-Binding Proteins
Concept MicroRNAs
Academic Article SUN1/2 and Syne/Nesprin-1/2 complexes connect centrosome to the nucleus during neurogenesis and neuronal migration in mice.
Academic Article SUN1 and SUN2 play critical but partially redundant roles in anchoring nuclei in skeletal muscle cells in mice.
Academic Article Mutations in QARS, encoding glutaminyl-tRNA synthetase, cause progressive microcephaly, cerebral-cerebellar atrophy, and intractable seizures.
Academic Article Nuclear migration: rock and roll facilitated by dynein and kinesin.
Academic Article Somatic mutations in cerebral cortical malformations.
Academic Article Cell-Type-Specific Alternative Splicing Governs Cell Fate in the Developing Cerebral Cortex.
Academic Article microRNAs play critical roles in the survival and recovery of Caenorhabditis elegans from starvation-induced L1 diapause.
Academic Article Syne-1 and Syne-2 play crucial roles in myonuclear anchorage and motor neuron innervation.
Grant Cell Type-specific Alternative Splicing Controls Cerebral Cortical Development
Academic Article Variants in ADD1 cause intellectual disability, corpus callosum dysgenesis, and ventriculomegaly in humans.
Academic Article Progenitor cell diversity in the developing mouse neocortex.
Academic Article Regulation of human cerebral cortical development by EXOC7 and EXOC8, components of the exocyst complex, and roles in neural progenitor cell proliferation and survival.
Grant Single cell detection of dynamic protein-RNA interaction
Academic Article Orgo-Seq integrates single-cell and bulk transcriptomic data to identify cell type specific-driver genes associated with autism spectrum disorder.
Academic Article PIE-seq: identifying RNA-binding protein targets by dual RNA-deaminase editing and sequencing.
Academic Article Single-cell long-read sequencing in human cerebral organoids uncovers cell-type-specific and autism-associated exons.
Academic Article Infernape uncovers cell type-specific and spatially resolved alternative polyadenylation in the brain.
Search Criteria
  • C
  • elegans
  • genetics